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目的观察急性心肌梗死患者血清视黄醇结合蛋白4(RBP4)的变化,探讨检测血清RBP4在急性心肌梗死中的意义。方法 59例急性心肌梗死(AMI)患者及冠脉介入手术后,31例非AMI患者,40例对照组,均采用酶联免疫吸附法(ELISA)测定血清RBP4水平。结果急性心肌梗死患者血清RBP4高于其他对照组(P﹤0.01),冠脉介入手术前后血清RBP4水平有明显变化(P﹤0.01)。结论 RBP4可作为急性心肌梗死早期诊断和疗效观察指标。
Objective To observe the changes of serum retinol binding protein 4 (RBP4) in patients with acute myocardial infarction and to explore the significance of detecting serum RBP4 in acute myocardial infarction. Methods Serum levels of RBP4 were determined by enzyme-linked immunosorbent assay (ELISA) in 59 patients with acute myocardial infarction (AMI) and after coronary intervention. 31 patients without AMI and 40 controls. Results Serum RBP4 in patients with acute myocardial infarction was significantly higher than that in other control groups (P <0.01). Serum RBP4 level before and after coronary intervention significantly changed (P <0.01). Conclusion RBP4 can be used as early diagnosis and treatment of acute myocardial infarction indicators.