目的:探讨妊娠期乙型肝炎病毒(HBV)重叠戊型肝炎病毒(HEV)感染对母婴结局的影响。方法:选取2011年3月~2012年3月间在该院妇产科住院并分娩的HEV感染孕妇62例,根据血清标志物将其分为单纯HEV感染组(单纯组)37例和HBV与HEV重叠感染组(重叠组)25例。对比两组孕妇的临床表现、实验室指标、孕妇妊娠结局、新生儿结局。结果:两组孕妇恶心、呕吐、乏力、尿黄的比例组间比较差异无统计学意义(P>0.05);两组孕妇血清丙氨酸氨基转移酶(ALT)、总胆红素(TB)水平和血浆凝血酶原时间(PT)组间比较差异无统计学意义(P>0.05);重叠组孕妇肝胆酸(CG)水平明显高于单纯组,差异有统计学意义(P<0.05);两组孕妇重症肝炎和产后出血的发生率比较差异均无统计学意义(P>0.05);重叠组胎儿窘迫、胎儿生长受限、新生儿窒息的发生率明显高于单纯组,差异有统计学意义(P<0.05)。结论:妊娠期HBV重叠HEV感染的孕妇更易出现胆汁淤积,重叠感染对围产儿的影响较母体更为明显。 Objective: To investigate the influence of hepatitis B virus (HBV) overlap hepatitis E virus (HEV) infection during pregnancy on maternal and infant outcomes. Methods: From March 2011 to March 2012, 62 pregnant women who were hospitalized and delivered in obstetrics and gynecology department of HEV were enrolled. According to the serum markers, 37 cases were divided into simple HEV infection group (simple group) and HBV HEV overlap infection group (overlap group) 25 cases. Compare the clinical manifestations of two groups of pregnant women, laboratory indicators, pregnant women, pregnancy outcomes, neonatal outcomes. Results: There was no significant difference in nausea, vomiting, fatigue and urinary yellow between the two groups (P> 0.05). Serum alanine aminotransferase (ALT), total bilirubin (TB) (P> 0.05). The levels of CG in pregnant women in the overlap group were significantly higher than those in the simple group (P <0.05). There was no significant difference between the two groups (P> 0.05). There was no significant difference in the incidence of severe hepatitis and postpartum hemorrhage between the two groups (P> 0.05). The incidence of fetal distress, fetal growth restriction and neonatal asphyxia in overlap group was significantly higher than that in simple group Significance (P <0.05). Conclusion: Pregnant women with HBV overlap HEV during pregnancy are more likely to have cholestasis, and the effect of overlap infection on perinatal children is more obvious than that of maternal.