由绿僵菌产生的、具有杀虫及医药活性的非核糖体环六脂肽类次级代谢产物——破坏素(destruxin)最早于1961年被发现,目前已经鉴定的结构类似物有6大类,39种。不同结构的破坏素不仅具有广谱的杀虫活性,同时对于癌症、老年痴呆和肝炎等疾病模型表现出不同程度的医药活性,但其生物合成途径一直不清楚。 The desubstatin, a secondary metabolite of insecticidal and medicinal active non-ribosylcyclohexapeptides derived from Metarhizium anisopliae, was first discovered in 1961. There are 6 structural analogues identified so far 39 species Different structural destructivities not only have broad-spectrum insecticidal activities, but also show different degrees of medicinal activity in disease models such as cancer, Alzheimer’s disease and hepatitis, but the biosynthetic pathway has not been clear.