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目的探讨高血压患者血浆D-二聚体浓度与高血压及靶器官损害的关系及临床意义。方法收集本院心内科门诊及住院的76例不同病期的高血压患者及45名正常者的血浆,根据高血压患者心血管危险分层标准以区分靶器官的损害程度,用ELISA法检测76例高血压患者及45名正常对照者的血浆例正常对照者的血浆D-二聚体。用完全随机设计多组均数比较的方差分析、dunnet-t法及Student-Newman-Keruls法进行统计分析。结果正常对照组与高血压组患者的血浆D-二聚体浓度比较,差异有统计学意义(F=4.32,P<0.01),各组与标准组之间分析显示(采用dunnet-t法):极高危组、高危组均与标准组比较,差异有明显统计学意义,两两比较结果显示(采用SNK法、即:Student-Newman-Keruls法):高危组与极高危组均与中危组及标准组差异有统计学意义。结论因极高危组与高危组高血压患者的D-二聚体含量较标准组存在显著的差异,而极高危组与高危组高血压又与靶器官的损伤有关,因此血浆D-二聚体浓度可以作为临床上判断高血压病严重程度及靶器官损害程度的一项指标。
Objective To investigate the relationship between plasma D-dimer concentration and hypertension and target organ damage in hypertensive patients and its clinical significance. Methods 76 patients with hypertension at different stages and 45 normal subjects were collected from outpatients and inpatients of cardiology department in our hospital. According to the criteria of cardiovascular risk stratification in hypertensive patients, the degree of target organ damage was determined by ELISA. In the plasma of patients with hypertension and 45 normal control subjects, plasma D-dimer was detected in normal controls. ANOVA, dunnet-t and Student-Newman-Keruls methods were used for statistical analysis with completely randomized multiple sets of mean comparison. Results There was significant difference in plasma D-dimer concentration between the normal control group and the hypertensive group (F = 4.32, P <0.01). Analysis of each group and the standard group (using dunnet-t method) : Extremely high-risk group, high-risk group were compared with the standard group, the difference was statistically significant, any pairwise comparison showed (using SNK method, namely: Student-Newman-Keruls method) Group and standard group differences were statistically significant. Conclusion There is a significant difference in the content of D-dimer between high-risk group and high-risk group compared with the standard group, while the high-risk group and high-risk group are related to the target organ damage. Therefore, plasma D-dimer Concentration can be used as an indicator of the severity of hypertension and target organ damage.