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铋掺杂硫化铜纳米晶用于CT成像指导的光热治疗已经引起了人们的广泛关注.然而,低剂量的铋掺杂CT信号弱,高剂量铋掺杂又会减弱硫化铜的光热效果.本文报道了一种多功能纳米探针,用两亲性高分子将油溶性Cu_(1.94)S和Bi_2S_3纳米晶同时封装于约85 nm大小的纳米微球中,用于CT成像指导光热治疗.多功能纳米探针中Cu_(1.94)S和Bi_2S_3纳米晶的量和比例能够灵活调节,从而得到较高的光热转换效率(~31%)和良好的CT成像能力(27.8 HU gL~(-1)).这些纳米探针在4T1荷瘤小鼠进行瘤内注射后,显示了良好的CT成像与肿瘤光热治疗效果.该复合纳米探针的制备方法还可用于其他多功能纳米探针的制备.
Bismuth-doped CuS nanocrystals have been attracting much attention for photothermal therapy guided by CT imaging.However, the weak dose of Bismuth-doped CT signals and the doping of high dose Bismuth will weaken the photothermal effects of CuS In this paper, a multifunctional nanoprobe was reported to encapsulate oil - soluble Cu 1.94 S and Bi 2 S 3 nanocrystals in nanospheres of about 85 nm with amphiphilic macromolecules for CT imaging to direct photothermal The amount and ratio of Cu1 (1.94) S and Bi2S3 nanocrystals in the multifunctional nano-probes can be flexibly adjusted to obtain high photothermal conversion efficiency (~ 31%) and good CT imaging ability (27.8 HU gL ~ (-1)) .These nanoparticles showed good CT imaging and tumor photothermal therapy after intratumoral injection of 4T1 tumor-bearing mice.The preparation method of the composite nanoprobe can also be applied to other multifunctional nano Preparation of probe.