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给正常成年猕猴每天一次皮下注射重组人粒细胞集落刺激因子 10 μg·kg-1·d-1(μKD)或 (和 )重组人干细胞因子 2 0、5 0和12 5 μKD ,前者给药 5天 ,后者 8天 ,观察国产重组人干细胞因子动员外周血干细胞的效果。结果表明 ,给药后外周血白细胞数最高值rhG CSF单独给药组为 2 0 6 % ,rhSCF单独给药为 2 0 0 % ,而两者联合给药后为 2 80 %～ 310 % ;外周血CFU GM较动员前分别升高 1 1、1 3和 5 8～7 9倍 ;3个联合动员组外周血CD34+ 细胞数分别为动员前的 2 0、2 4和 35倍。说明rhSCF对外周血干 /祖细胞有明显的动员作用 ,rhSCF+rhG CSF联合动员效果更佳
Normal adult rhesus monkeys were injected subcutaneously with recombinant human granulocyte colony-stimulating factor 10 μg · kg -1 · d -1 (μKD) or (and) recombinant human stem cell factor 2 0, 50 and 125 μKD subcutaneously once daily for 5 days Day, the latter eight days to observe the effect of domestic recombinant human stem cell factor mobilization of peripheral blood stem cells. The results showed that the highest number of peripheral white blood cells after administration of rhG CSF alone was 26%, rhSCF alone was administered 200%, while the two combined administration of 280% to 310%; peripheral Blood CFU GM increased by 1 1,13 and 5 8 ~ 7 9 times respectively before mobilization; the number of CD34 + cells in peripheral blood of 3 combined mobilization groups was 20, 24, 35 times before mobilization. RhSCF on peripheral blood stem / progenitor cells have a clear mobilization effect, rhSCF + rhG CSF joint mobilization better