论文部分内容阅读
目的 :探讨小而密低密度脂蛋白 (sLDL)、血浆脂蛋白 (a)〔Lp(a)〕、载脂蛋白 (apo)A 1及apoB 10 0水平与冠状动脉狭窄程度之间的关系。方法 :对 10 2例因胸痛而就诊的患者行选择性冠状动脉造影。分别测定患者血浆sLDL ,血浆Lp(a)、apoA 1、apoB 10 0水平及其他血脂成分。 结果 :冠状动脉有病变组与无病变组血浆Lp(a)及sLDL水平存在显著差异 (P <0 .0 5 )。相关分析表明 ,只有血浆sLDL水平与冠状动脉狭窄程度成正相关 (r =0 .1932～ 0 .2 70 3,P <0 .0 1)。结论 :血浆sLDL亚组份代谢紊乱与冠状动脉狭窄的发生与发展有内在联系 ,对于预测有无冠状动脉病变及其进展有一定临床意义
Objective: To investigate the relationship between the levels of sLDL, plasma lipoprotein (a) [Lp (a)], apolipoprotein A 1 and apoB 10 0 and the degree of coronary artery stenosis. Methods: Selective coronary angiography was performed in 102 patients who had chest pain. Plasma sLDL, plasma Lp (a), apoA 1, apoB 10 0 levels and other blood lipid components were measured. Results: Plasma levels of Lp (a) and sLDL in the diseased and non-diseased coronary arteries were significantly different (P <0.05). Correlation analysis showed that plasma sLDL levels were positively correlated with the degree of coronary stenosis (r = 0.1932-0.2703, P <0.01). Conclusion: The metabolic disorder of plasma sLDL subunits is intrinsically linked with the occurrence and development of coronary artery stenosis, which is of clinical significance for predicting the presence or absence of coronary artery disease and its progression