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目的:探讨糖皮质激素治疗急性肺损伤的临床应用。方法:选取本院2010年3月—2013年12月之间诊治的急性肺损伤患者60例,随机分为对照组和观察组,对照组采用常规氧疗,病情严重者给予有创或无创通气,加抗生素和相应的支持治疗。观察组在对照组治疗的基础上加用甲基强的松龙静脉注射。结果:观察组ARDS发生率为10%、对照组发生率为16.7%,两组比较差异无统计学意义(p>0.05);观察组无死亡病例,对照有3例死亡病例,两组患者死亡率比较有统计学意义(p<0.05);观察组患者住院时间及氧合指数恢复时间较对照组均有明显减少,差异具有统计学意义(p<0.05)。结论:由本次临床研究结果可知,在常规治疗的基础上采用糖皮质素治疗急性肺损伤可取得良好的治疗效果。
Objective: To investigate the clinical application of glucocorticoid in the treatment of acute lung injury. Methods: Sixty patients with acute lung injury diagnosed and treated in our hospital from March 2010 to December 2013 were randomly divided into control group and observation group. The control group received conventional oxygen therapy. Patients in severe condition were given invasive or non-invasive ventilation , Plus antibiotics and the corresponding supportive treatment. Observation group in the control group based on the treatment plus methylprednisolone intravenously. Results: The incidence of ARDS was 10% in the observation group and 16.7% in the control group, with no significant difference between the two groups (p> 0.05). There were no deaths in the observation group, 3 deaths in the control group and two deaths in both groups (P <0.05). The hospitalization time and oxygenation index recovery time in the observation group were significantly reduced compared with the control group, the difference was statistically significant (p <0.05). Conclusion: From the results of this clinical study, we can see that glucocorticoid treatment of acute lung injury can achieve good therapeutic effects on the basis of conventional treatment.