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目的:评价运动疗法对血液透析患者不宁腿综合征的有效性和安全性。方法:通过中国生物医学文献数据库、CNKI、万方数据库、维普中文生物医学期刊数据库、PubMed、CINAHL、EMBASE、Springer、Cochrane等数据库全面检索相关的随机对照试验文献，并用RevMan5.3软件进行meta分析。结果:最终纳入6篇文献。Meta分析结果显示，运动疗法可以改善血液透析患者不宁腿综合征的严重程度[WMD＝-8.58，95%可信区间(-13.91～-3.25), n P＝0.002]，改善血液透析患者的抑郁程度[WMD＝-6.27，95%可信区间(-9.53～-3.00), n P<0.001]和嗜睡程度[WMD＝-1.32，95%可信区间(-2.50～-0.14)，n P＝0.03]。其中5篇文献表明运动疗法未引发不良反应和不宁腿综合征加重。n 结论:运动疗法可有效改善血液透析患者不宁腿综合征、抑郁和嗜睡程度，且具有一定安全性。“,”Objective:To systematically evaluate the efficacy and safety of exercise therapy on restless legs syndrome (RLS) in hemodialysis patients by meta-analysis.Methods:We searched RCTs in CBM, CNKI, Wanfang Database, VIP Database, PubMed, CINAHL, EMbase, Springer, and Cochrane library. The RCTs which we searched were exercise therapy in RLS among hemodialysis patients. RevMan 5.3 was used to analyze the data.Results:A total of 6 studies were included. Meta-analysis showed that exercise therapy could improve RLS in hemodialysis patients(WMD= -8.58, 95% n CI (-13.91, -3. 25), n P=0.002); at the same time, it could improve their depression(WMD=-6.27, 95% n CI (-9.53, -3.00), n P<0.001)and sleepiness(WMD=-1.32, 95%n CI (-2.50, -0.14), n P=0.03). Five RCTs showed no adverse reactions and even worse RLS.n Conclusion:Exercise therapy can effectively improve RLS, depression and sleepiness in hemodialysis patients and is relatively safe.