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目的 :提高对膀胱嗜铬细胞瘤的认识 ,探讨该病的诊断和治疗。方法 :总结 4例膀胱嗜铬细胞瘤的临床表现、诊断和治疗经验 ,并复习相关文献。结果 :所有患者均表现为与排尿有关的心悸、出冷汗、头痛等高儿茶酚胺大量释放症状 ;4例均有血浆和 /或 2 4h尿中儿茶酚胺及VMA增高 ,结合B超、CT、MRI或膀胱镜可发现膀胱壁占位性病变。 4例均行膀胱部分切除或肿瘤剜除术 ,经病理检查确诊 ,随访未见肿瘤复发。结论 :对于排尿后出现的心悸、出冷汗、头痛等症状的患者 ,应高度怀疑膀胱嗜铬细胞瘤 ,检测血浆和尿中儿茶酚胺及其代谢产物结合。影响学和膀胱镜检查可明确该病的定性和定位诊断 ,膀胱部分切除或肿瘤剜除术是有效的治疗方法。
Objective: To improve the understanding of bladder pheochromocytoma, to explore the diagnosis and treatment of the disease. Methods: The clinical manifestations, diagnosis and treatment experience of 4 cases of bladder pheochromocytoma were summarized, and the related literatures were reviewed. Results: All the patients showed symptoms of massive release of catecholamines, such as palpitation, cold sweat, and headache. Urinary catecholamines and VMA were elevated in 4 and 4 patients respectively. Combined with B-ultrasound, CT, MRI or bladder Bladder wall lesions can be found. All the 4 cases underwent resection of the bladder or tumor removal and operation, confirmed by pathological examination. No tumor recurrence was observed at follow-up. CONCLUSIONS: Bladder pheochromocytoma should be highly suspected in patients with palpitations, cold sweats, headaches and other symptoms after urination. The combination of catecholamines and their metabolites in plasma and urine should be examined. Influenza and cystoscopy can confirm the diagnosis and localization of the disease, partial resection of the bladder or tumor resection is an effective treatment.