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目的:探讨新疆不同民族贲门腺癌与非癌组织中IGF-IR、p53的异常表达及其病理学意义。方法:应用免疫组化LSAB法检测93例贲门腺癌和21例非癌组织的IGF-IR、p53水平,并分析其表达与病理学意义。结果:(1)IGF-IR、p53在贲门腺癌组织中的检出率分别为84.95%(79/93)、75.27%(70/93),在贲门非癌组织中的阳性检出率分别为47.62%(10/21)、4.76%(1/21),差异均有统计学意义(P<0.01)。(2)哈萨克、维吾尔、汉族民族间IGF-IR、p53阳性率差别均无统计学意义(P>0.05)。(3)p53的阳性表达与组织分级无关(P>0.05),而与淋巴结转移相关(P<0.05)。IGF-IR的阳性表达与贲门腺癌组织学分级及淋巴结转移无明显关系(P>0.05)。(4)贲门腺癌中IGF-IR与p53间未发现有相关关系(P>0.05)。结论:IGF-IR和p53的异常表达在贲门腺癌变过程中具有重要作用。
Objective: To investigate the abnormal expressions of IGF-IR and p53 in gastric cardia adenocarcinoma and non-cancerous tissues in Xinjiang and their pathological significance. Methods: The expressions of IGF-IR and p53 were detected by immunohistochemical LSAB method in 93 cases of GCA and 21 cases of non-cancer tissues. The expression and pathological significance were also analyzed. Results: (1) The positive rates of IGF-IR and p53 in gastric cardia adenocarcinoma were 84.95% (79/93) and 75.27% (70/93), respectively. The positive rates of IGF-IR and p53 in gastric cardia adenocarcinoma were 47.62% (10/21), 4.76% (1/21) respectively, the difference was statistically significant (P <0.01). (2) There was no significant difference in the positive rates of IGF-IR and p53 among Kazak, Uighur and Han nationalities (P> 0.05). (3) The positive expression of p53 was not related to the histological grade (P> 0.05), but correlated with lymph node metastasis (P <0.05). The positive expression of IGF-IR had no significant relationship with histological grade and lymph node metastasis of GCA (P> 0.05). (4) There was no correlation between IGF-IR and p53 in GCA (P> 0.05). Conclusion: The abnormal expression of IGF-IR and p53 plays an important role in the carcinogenesis of GCA.