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采用临床对照研究来探究身材矮小儿童青春期激素水平及体重指数的相关性。本研究选取身材矮小患儿208例,男性122例(10~14岁),女性86例(8~13岁),其中进入青春期(TannerⅡ~Ⅳ期)的发育组患儿104例,对照组为年龄性别匹配的未发育组患儿104例。所有患儿由内分泌专科医师进行体检,行空腹行精氨酸-可乐定生长激素激发试验;完善甲状腺功能、生化、IGF1、胰岛素、C肽、血糖测定及左手骨龄片检查。结果表明患儿在青春期的IGF1、胰岛素、C肽及血糖浓度均有统计学意义,而生长激发试验、骨龄增高以及甲状腺功能无统计学意义,说明身材矮小患儿青春期GH-IGF1轴反应受损;虽然发育组较未发育组有身高的增长,但仍明显低于正常;最终发现进行完善的体检和实验室检查,特别是IGF1、胰岛素、C肽及血糖等指标利于早期发现不同病因矮小患者,提高诊断治疗水平。
A controlled clinical trial was conducted to investigate the correlation between puberty hormone levels and body mass index in short stature children. In this study, 208 cases of short stature were selected, including 122 males (aged from 10 to 14 years) and 86 females (aged from 8 to 13 years). Among them, 104 children in the developmental group in adolescence (TannerⅡ ~ Ⅳ) Age-matched non-developed group of children with 104 cases. All children were examined by endocrinologists and were given fasting arginine-clonidine stimulation test. Thyroid function, biochemistry, IGF1, insulin, C-peptide, blood sugar and left-hand age were examined. The results showed that children with adolescent IGF1, insulin, C-peptide and blood glucose concentrations were statistically significant, but the growth stimulation test, increased bone age and thyroid function was not statistically significant, indicating short stature in children with puberty GH-IGF1 axial response impaired ; Although the development group than the non-development group height growth, but still significantly lower than normal; finally found that the perfect physical examination and laboratory tests, especially IGF1, insulin, C-peptide and blood glucose and other indicators conducive to the early discovery of different causes of short patients , Improve diagnosis and treatment level.