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现已发现 ,ｐ５３基因的突变是人类肿瘤发生发展过程中最常见的基因事件 ,与口腔癌发生发展的关系密切。本研究采用单链构象多态性分析（ＰＣＲ -ＳＳＣＰ）技术 ,对３５例舌鳞癌组织及２０例正常舌粘膜的 ｐ５３基因第７ ,８外显子和第７内含子突变进行检测 ,并分析它与舌鳞癌
It has been found that the mutation of p53 gene is the most common genetic event in the development of human tumors and closely related to the occurrence and development of oral cancer. In this study, single-strand conformation polymorphism (PCR-SSCP) was used to detect the mutations of exon 7 and exon 7 and intron 7 of p53 gene in 35 cases of tongue squamous cell carcinoma and 20 cases of normal tongue mucosa. And analyze it with tongue squamous cell carcinoma