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目的探讨贝那普利联合美托洛尔治疗老年慢性心力衰竭患者的临床疗效。方法选取2014年1月至2015年1月沈阳市红十字会医院收治的老年慢性心力衰竭患者48例,按随机数字表法将其分为观察组与对照组,各24例。对照组患者给予常规对症治疗,观察组患者在对照组基础上采用贝那普利联合美托洛尔进行治疗,比较两组患者的临床疗效、血浆脑钠肽(BNP)、6 min步行试验(6MWT)距离及不良反应发生情况。结果观察组患者治疗的总有效率明显高于对照组,差异有统计学意义(P<0.05);治疗6个月后,观察组患者的BNP水平明显低于对照组,6MWT距离明显长于对照组,差异均有统计学意义(均P<0.05);两组患者不良反应发生率差异无统计学意义(P>0.05)。结论贝那普利联合美托洛尔治疗老年慢性心力衰竭患者临床疗效确切,可有效降低BNP水平,促进患者心功能恢复,且安全性较高。
Objective To investigate the clinical efficacy of benazepril combined with metoprolol in the treatment of elderly patients with chronic heart failure. Methods Forty-eight elderly patients with chronic heart failure admitted to Shenyang Red Cross Hospital from January 2014 to January 2015 were randomly divided into observation group and control group with 24 cases in each group. The patients in the control group were given conventional symptomatic treatment. The patients in the observation group were treated with benazepril combined with metoprolol on the basis of the control group. The clinical efficacy, plasma BNP, 6 min walk test ( 6MWT) distance and the occurrence of adverse reactions. Results The total effective rate of observation group was significantly higher than that of control group (P <0.05). After 6 months of treatment, the BNP level of observation group was significantly lower than that of control group, and the distance of 6MWT was significantly longer than that of control group (All P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion The combination of benazepril and metoprolol in elderly patients with chronic heart failure has definite clinical curative effect, which can effectively reduce the level of BNP and promote the recovery of cardiac function in patients with high safety.