目的合成3个重要的药物中间体。方法以乳酸乙酯、卤代烷为起始原料,通过烷基化、格氏化、还原、胺解、成盐5步反应得到目标化合物。结果与结论合成目标化合物2-甲氧基-3-戊胺盐酸盐(1)、2-乙氧基-3-戊胺盐酸盐(2)和2-乙氧基-N-甲基-3-戊胺盐酸盐(3),收率分别为18.1%、18.8%、14.3%。目标化合物的结构经MS和1H-NMR谱确证。 Objective To synthesize three important drug intermediates. Methods Starting from ethyl lactate and alkyl halides, the target compound was obtained by alkylation, Grignard reaction, reduction, amineysis and salt formation in 5 steps. Results and conclusion The target compounds 2-methoxy-3-pentylamine hydrochloride (1), 2-ethoxy-3-pentylamine hydrochloride (2) and 2-ethoxy- Pentanamine hydrochloride (3) were obtained in yields of 18.1%, 18.8% and 14.3%, respectively. The structure of the target compound was confirmed by MS and 1H-NMR spectroscopy.