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多发性骨髓瘤(multiple myeloma,MM)是一种恶性浆细胞疾病,其肿瘤细胞起源于骨髓中的浆细胞。大多数MM患者年龄大于40岁,且至今该疾病仍难以治愈。周围神经病变(peripheral neuropathy,PN)在MM患者中的发生率很高,其中由MM治疗引起的PN发生率为37%~83%。很长一段时间,MM导致的PN被认为是继发于浆细胞疾病本身,但近年来随着新型靶向药物的应用,医源性PN的发病率正逐渐升高。
Multiple myeloma (MM) is a malignant plasma cell disease whose tumor cells originate from plasma cells in the bone marrow. Most MM patients are over 40 years of age and so far the disease remains refractory. The incidence of peripheral neuropathy (PN) in MM patients is very high, among which the incidence of PN caused by MM treatment is 37% -83%. For a long time, PN caused by MM is considered secondary to plasma cell disease itself, but with the application of new targeted drugs in recent years, the incidence of iatrogenic PN is gradually increased.