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血浆内皮素(ET)是一种低分子的血管活性肽,具有细胞信使样的生理活性,有收缩血管、促进血管平滑肌增生与细胞粘连的作用。血浆内皮素水平升高可使血管痉挛,血栓形成与动脉粥样硬化,是心脑血管疾病发生发展的原因之一。中药治疗心脑血管疾病有着良好的疗效,其机理可能作用于血浆内皮素等环节。冠脉斑块阻塞或冠脉痉挛引起缺血缺氧会刺激局部心肌组织合成和释放大量血浆内皮素1(ET1),而血浆内皮素1的增多又会加重心肌缺血缺氧及产生细胞毒效应,形成恶性循环。所以,目前降低血浆内皮素1含量及活性已成为冠心病治疗用药选择的关键。
Plasma endothelin (ET) is a low-molecular-weight vasoactive peptide that has the function of cell-cell-like physiology and has the function of contracting blood vessels, promoting vascular smooth muscle proliferation and cell adhesion. Plasma endothelin levels can make vasospasm, thrombosis and atherosclerosis, is one of the causes of the development of cardiovascular and cerebrovascular diseases. Chinese medicine treatment of cardiovascular and cerebrovascular diseases has a good effect, the mechanism may be the role of plasma endothelin and other links. Coronary plaque block or coronary artery spasm caused by ischemia and hypoxia will stimulate the synthesis and release of a large number of local myocardial tissue plasma endothelin 1 (ET1), and increased plasma endothelin 1 will increase myocardial ischemia and hypoxia and produce cytotoxic Effect, forming a vicious circle. Therefore, the current reduction of plasma endothelin 1 content and activity has become the key to the choice of treatment of coronary heart disease.