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出生体重小于1,500克的早产儿出现呼吸暂停可达30％,重度呼吸暂停时伴有紫绀、心动过缓及低血压等表现。呼吸暂停反复发作可导致神经系统后遗症。呼吸暂停时可采用触觉刺激、机械呼吸及药物治疗。按12～16毫克/公斤/天投予茶碱治疗呼吸暂停的婴儿可引起严重的毒性作用。作者研究了小剂量茶碱对早产儿特发性呼吸暂停的疗效与毒性作用。研究对象的呼吸暂停及心跳减慢均严重,需用触觉刺激或机械呼吸治疗。对16小时内反复发作6次以上的小儿,共治疗7名。首剂按2.5毫克/公斤,8小时后按2毫克/公斤/天,分三剂经胃管给予。测定血药物浓度,并研究观察他们呼吸暂停次数及心率,动
Preterm infants with a birth weight of less than 1,500 grams have apnea up to 30% and cyanotic, bradycardia, and hypotension during severe apnea. Recurrent apnea can lead to nervous system sequelae. Apnea can be used when the tactile stimulation, mechanical breathing and drug treatment. Infants treated with theophylline at apnea at 12-16 mg / kg / day can cause severe toxic effects. The authors studied the efficacy and toxicity of low-dose theophylline in premature infants with idiopathic apnea. The study subjects had severe apnea and slow heartbeat, requiring tactile stimulation or mechanical respiration. On repeated attacks within 16 hours more than 6 children, a total of seven treatment. The first dose by 2.5 mg / kg, 8 mg / kg / day 8 hours, three doses administered by the stomach. Blood drug concentrations were measured and their apnea frequency and heart rate were observed