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目的了解安徽省巢湖地区新布尼亚病毒感染患者的临床特点和病重相关危险因素。方法回顾性分析2012年4月~2015年11月安徽医科大学附属巢湖医院确诊的发热伴血小板减少综合征布尼亚病毒(severe fever with thrombocytopenia syndrome bunyavirus,SFTSV)(简称“新布尼亚病毒”)感染住院病例,采用描述流行病学方法对确诊的病例流行特征、临床特点进行分析,并用单因素Logistic回归分析与病情严重程度相关危险因素。结果安徽省巢湖地区2012-2015年共报告57例发热伴血小板减少综合征(severe fever with thrombocytopenia syndrome,SFTS),病死率为19.3%,且该地区SFTSV感染的病例呈逐年上升趋势,而农民及高龄是重症组的高危因素;4~9月为该病流行季,发病月份主要集中在5~6月份;经单因素Logistic回归分析,发现意识障碍(OR=14.236,95%CI:1.324~152.091)、血尿(OR=2.583,95%CI:1.114~5.990)和空腹葡萄糖升高(OR=34.838,95%CI:2.113~569.427)对病情严重程度具有预测作用。结论患者一旦出现意识障碍、血尿及空腹葡萄糖升高时,提示其病情危重,应引起医护人员的足够重视。
Objective To investigate the clinical features and the risk factors associated with New Bunia virus infection in Chaohu Lake, Anhui Province. Methods The clinical data of severe fever with thrombocytopenia syndrome bunyavirus (SFTSV) diagnosed in Chaohu Hospital Affiliated to Anhui Medical University from April 2012 to November 2015 were retrospectively analyzed. ") Inpatients, epidemiological characteristics of the confirmed cases, clinical features were analyzed by descriptive epidemiological method, and the risk factors associated with the severity of the disease were analyzed by single factor Logistic regression. Results A total of 57 cases of fever with thrombocytopenia syndrome (SFTS) were reported in Chaohu District of Anhui Province during 2012-2015. The case fatality rate was 19.3%. The incidence of SFTSV infection in this area showed an upward trend year by year. However, The elderly were the risk factors of severe group. The epidemic season was from April to September, and the onset month was mainly from May to June. Uni-Logistic regression analysis showed that the disturbance of consciousness (OR = 14.236, 95% CI: 1.324-152.091 ), Hematuria (OR = 2.583, 95% CI: 1.114-5.990) and fasting glucose (OR = 34.838,95% CI: 2.113-596.427) had a predictive value for the severity of the disease. Conclusions In patients with disturbance of consciousness, hematuria and fasting glucose, suggesting that the critical condition, should pay enough attention to medical staff.