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Objective: The aim of our study was to investigate the effects of interleukin-18 (IL-18) on implanted Lewis lung cancer in suppressing tumor growth and inducing tumor cells apoptosis. Methods: One week after hypodermic inoculation of Lewis cells, sixteen tumor-bearing syngeneic mice were randomly divided into two groups. The mice in the treatment group were intraperitoneal injected with the IL-18, in the control group were intraperitoneal injected with normal saline. The health conditions of the mice were measured, the morphology of the tumors was studied and the apoptosis of implanted lung cancer cells was detected by TUNEL to evaluated the effects of IL-18. Results: IL-18 had no significant effects on the health condi-tions of the mice, but it could suppress the implanted tumor growth (inhibition rate was 75%) and induce tumor cells apoptosis. Conclusion: IL-18 can suppress the implanted Lewis lung cancer cells by way of inducing tumor cells apoptosis. It could be used as a new strategy for lung cancer.