旨在探讨锰的累积暴露水平与神经行为改变之间的剂量效应关系。对１３９名锰铁冶炼工人和９３名电焊工人进行了研究。研究内容包括空气锰采样测定和神经行为功能测定；同时依据空气锰浓度和接触工龄计算出累积接触指数。相关分析发现神经行为功能改变与累积接触水平之间存在剂量效应关系。 The purpose of this study was to investigate the dose-response relationship between accumulated manganese exposure and neurobehavioral changes. 139 ferromanganese smelters and 93 welders were studied. The research contents include air manganese sampling determination and neurobehavioral function determination, and the cumulative contact index is calculated based on the air manganese concentration and exposure time. Correlation analysis found that there was dose-response relationship between neurobehavioral changes and cumulative exposure.