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目的:探讨急性呼吸道感染患儿白细胞(WBC)计数、血清内毒素(ET)、C反应蛋白(CRP)水平变化及临床应用价值。方法:对急性呼吸道感染组106例患儿(细菌感染组62例、病毒感染组44例)进行WBC计数、血清ET、CRP水平等指标进行检测,并与正常对照组的40例健康儿童进行比较分析。结果:急性呼吸道感染组患儿WBC计数、血清ET、CRP水平均显著高于正常对照组,差异具有统计学意义(P<0.05或P<0.01);血清ET、CRP水平对诊断脓毒症的敏感性差异无显著性(P>0.05),均显著高于WBC计数,差异具有统计学意义(P<0.05);WBC计数特异性显著高于ET、CRP水平,ET水平特异性显著低于CRP,差异均具有统计学意义(P<0.05);细菌感染组患儿血清ET、CRP水平显著高于病毒感染组,差异具有统计学意义(P<0.05),而两组间WBC计数差异不显著(P>0.05)。结论:测定WBC计数、ET、CRP对急性呼吸道感染患儿具有一定的诊断价值。
Objective: To investigate the changes of white blood cell count (WBC), serum endotoxin (ET) and C-reactive protein (CRP) in children with acute respiratory infection and its clinical value. Methods: WBC count, serum ET and CRP levels were measured in 106 children with acute respiratory tract infection (62 in bacterial infection group and 44 in virus infection group), and compared with 40 healthy children in normal control group analysis. Results: The WBC counts, serum ET and CRP levels in children with acute respiratory infection were significantly higher than those in the normal control group (P <0.05 or P <0.01). Serum levels of ET and CRP were significantly higher in patients with sepsis (P <0.05), the difference was statistically significant (P <0.05); the specificity of WBC count was significantly higher than that of ET and CRP, and the specificity of ET level was significantly lower than that of CRP (P <0.05). The levels of serum ET and CRP in bacterial infection group were significantly higher than those in virus infection group (P <0.05), but there was no significant difference between the two groups (P> 0.05). Conclusion: The determination of WBC count, ET, CRP in children with acute respiratory infection has a certain diagnostic value.