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目的探讨华法林用于治疗老年房颤患者的临床效果。方法选取我院2006年1月至2008年12月收治的老年房颤患者124例,将患者随机平均分为两组,分别进行华法林与阿司匹林药物治疗,对比分析治疗结果。结果观察组62例患者终点事件中,缺血性脑卒中1例(1.61%)、暂时性脑缺血1例(1.61%)、无外周动脉栓塞与死亡病例,与对照组相比,缺血性脑卒中与暂时性脑缺血发生率比较,差异有统计学意义(P<0.05)。两组患者均无严重出血情况发生,观察组上消化道出血1例,年龄为74岁,INR为3.12,停药后进行止血与胃黏膜保护治疗后出血情况消失,未进行输血治疗。两组患者中齿龈与皮肤出血为2例和3例,停药后症状消失。结论华法林在房颤治疗中有效降低了缺血性脑卒中、暂时性脑缺血的发生率,起到了良好的临床效果,但是不可忽视的出血等不良反应需要在治疗中密切观察,避免危险发生。
Objective To investigate the clinical effect of warfarin in the treatment of elderly patients with atrial fibrillation. Methods A total of 124 elderly AF patients were selected from January 2006 to December 2008 in our hospital. The patients were randomly divided into two groups. Warfarin and aspirin were used to treat the patients. The treatment outcome was compared. Results Among the 62 patients in the observation group, ischemic stroke was found in 1 case (1.61%), transient ischemic attack in 1 case (1.61%), no peripheral arterial embolism and death. Compared with the control group, ischemia The incidence of stroke and transient ischemic attack, the difference was statistically significant (P <0.05). No severe bleeding occurred in both groups. One case of upper gastrointestinal bleeding was observed in the observation group, with an age of 74 years and an INR of 3.12. Bleeding was stopped after hemostasis and gastric mucosal protection treatment after stopping the treatment. Blood transfusion was not performed. Two groups of patients with gums and skin hemorrhage in 2 cases and 3 cases, withdrawal symptoms disappeared. Conclusions Warfarin can effectively reduce the incidence of ischemic stroke and transient ischemic attack in the treatment of atrial fibrillation, and has a good clinical effect. However, adverse reactions such as hemorrhage, which can not be ignored, need to be closely observed during treatment to avoid Dangerous.