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目的 :提高对遗传性非息肉病性大肠癌本质的认识。 方法 :对四个有遗传性非息肉病性大肠癌家系进行调查。结果 :四家系共有 14例病人 ,发病时平均年龄 43岁。 6 1.9% (13/ 2 1)的癌灶位于脾曲近端的大肠。大肠多原发癌占 35 .7% (5 /14)。无结肠息肉病。四家系中之一为癌家族综合征。 结论 :对遗传性非息肉病性大肠癌病人及其家系成员要进行严密监测 ,争取疾病早诊断早治疗 ,提高治疗效果。
Objectives: To improve the understanding of the nature of hereditary nonpolyposis colorectal cancer. Methods: Four families with hereditary nonpolyposis colorectal cancer were investigated. Results : There were 14 patients in four families. The average age at the time of onset was 43 years. 6 1.9% (13/21) of foci were located in the large intestine of the proximal spleen. Most primary colorectal cancers accounted for 35.7% (5/14). No colon polyposis. One of the four families is cancerous family syndrome. Conclusion : The patients with hereditary nonpolyposis colorectal cancer and their family members should be closely monitored for early diagnosis and early treatment of the disease to improve the treatment effect.