【摘 要】
：
The title compound(E)-4-tert-butyl-N-(2,4-dichlorobenzylidene)-5-(1,2,4-triazol-1-yl)-thiazol-2-amine was synthesized by the reaction of 4-tert-butyl-5-(1,2,4-t
【机 构】
：
College of Chemistry and Chemical Engineering
论文部分内容阅读
The title compound(E)-4-tert-butyl-N-(2,4-dichlorobenzylidene)-5-(1,2,4-triazol-1-yl)-thiazol-2-amine was synthesized by the reaction of 4-tert-butyl-5-(1,2,4-triazol-1-yl)-thia-zol-2-amine with 2,4-dichlorobenzaldehyde,and its crystal structure was determined by single-crystal X-ray diffraction.The crystal belongs to the triclinic system,space group P-1 with a=7.9748(4),b=10.1803(5),c=11.4603(6)(A),a=102.882(1),β=100.253(1),γ=104.457(1)°,V=850.95(7)(A)3,Z=2,F(000)=392,C16H15Cl2N5S,Mr=380.29,Dc=1.484 g/cm3,S=1.095,μ=0.512 mm-1,the final R=0.0301 and wR=0.0965 for 3334 observed reflections(I>2σ(I)).The preliminary antitumor activity shows that for the title compound the IC50 of Hela is 0.175μmol/mL and that of Bel7402 is 0.156 μmol/mL.
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