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近年来,肾上腺皮质的功能和慢性气管炎的关系,无论在实验和临床上都证明非常密切。临床方面报导,慢性气管炎患者24小时尿内17-酮皮质类固醇和17-羟皮质类固醇普遍低于健康人,特别是肾阳虚患者 ACTH 应答反应迟缓低下,提示了肾上腺储备功能下降。我院生化组报导,实验性慢性气管炎大白鼠尿内17-酮皮质类固醇和17-羟皮质类固醇亦较正常大白鼠低。上述资料均为生化学方面的研究,有关病理形态学的研究尚很少。本实验的目的,通过慢性气管炎的动物模型,观察肾上腺的病理变化,结合组织化学定位定性和定量,以估计慢性气管炎大白鼠的肾上腺功能状态,进一步探讨肾上腺功能和慢性气管炎的关系。材料和方法实验动物,选择健康大白鼠36只,体重120g 左右,分成实验组(24只)和对照组(12
In recent years, the relationship between the function of adrenal cortex and chronic bronchitis, both in the experimental and clinical have proved very close. Clinical reports, 24-hour urinary urinary 17-ketocorticosteroids and 17-hydroxy corticosteroids in patients with chronic bronchitis generally lower than healthy people, especially in patients with deficiency of ACTH response slow response, suggesting a decline in adrenal reserve. Biochemical Group reported in our hospital, experimental chronic bronchitis in rats with urinary 17-keto-steroids and 17-hydroxy corticosteroids are also lower than normal rats. The above information are biochemical aspects of the study, the pathological morphology of the study is still very small. The aim of this study was to observe the pathological changes of the adrenal gland by animal models of chronic bronchitis and to determine the status of adrenal glands in rats with chronic bronchitis by qualitative and quantitative histochemical localization and to further explore the relationship between adrenal function and chronic bronchitis. MATERIALS AND METHODS: Thirty-six healthy rats were selected and weighed 120g, divided into experimental group (24) and control group (12)