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目的:研究婴幼儿腹泻乳糖不耐受的发生率;轮状病毒肠炎与其他腹泻病的乳糖不耐受发生率的比较;婴幼儿腹泻去乳糖饮食的疗效分析。方法:采用尿半乳糖测定法判断有无乳糖酶缺乏。应用双抗体夹心法测定粪便轮状病毒抗原(RV-Ag),判断患儿有无感染轮状病毒。分组观察婴幼儿腹泻去乳糖饮食的疗效。结果:婴幼儿腹泻乳糖不耐受的发生率为62.24%。其中≤1岁乳糖不耐受的发生率为67.56%,>1岁乳糖不耐受的发生率为53.56%,差异有统计学意义(P<0.05)。RV-Ag(+)乳糖不耐受的发生率58.21%,RV-Ag(-)乳糖不耐受的发生率47.22%,差异无统计学意义(P>0.05)。婴幼儿腹泻乳糖不耐受去乳糖饮食有效率90.00%,对照组有效率52.50%,差异有统计学意义(P<0.01)。结论:①婴幼儿腹泻时乳糖不耐受发生率高达62.24%,随年龄增加而显著降低;②轮状病毒肠炎继发乳糖不耐受高于其他腹泻病,但差异无统计学意义;③婴幼儿腹泻时继发乳糖不耐受可加重腹泻症状,是使腹泻时间延长的重要原因,去乳糖饮食疗效肯定。
PURPOSE: To study the incidence of lactose intolerance in infants with diarrhea; to compare the incidence of lactose intolerance with rotavirus enteritis and other diarrheal diseases; and to analyze the efficacy of lactobacillus diet for diarrhea in infants and young children. Methods: Determination of urine galactose with or without lactase deficiency. Application of double antibody sandwich method for the determination of stool rotavirus antigen (RV-Ag), to determine whether children infected with rotavirus. Group observation of infantile diarrhea to lactose diet efficacy. Results: The incidence of lactose intolerance in infants and young children was 62.24%. Among them, the incidence of lactose intolerance ≤1 years old was 67.56%, and the incidence of lactose intolerance> 1 year old was 53.56%, the difference was statistically significant (P <0.05). RV-Ag (+) lactose intolerance rate was 58.21%, RV-Ag (-) lactose intolerance rate was 47.22%, the difference was not statistically significant (P> 0.05). Infants and young children lactose intolerance lactose intolerance diet 90.00% effective rate 52.50%, the difference was statistically significant (P <0.01). Conclusions: ①The incidence of lactose intolerance in infants and young children is as high as 62.24%, which decreases significantly with age. ② The lactose intolerance secondary to rotavirus enteritis is higher than other diarrheal diseases, but the difference is not statistically significant. ③The infants Secondary diarrhea secondary to lactose intolerance can aggravate diarrhea symptoms, diarrhea is an important reason for the extension of time, to the positive effect of lactose diet.