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目的 探讨细胞凋亡和bcl 2及p5 3蛋白在胃肠道粘膜相关淋巴组织 (MALT)淋巴瘤中的表达与MALT淋巴瘤恶性程度及预后的关系。方法 收集我院 1990年 1月～ 1998年 12月胃肠道MALT淋巴瘤 32例 ,行免疫组织化学染色方法检测bcl 2和p5 3蛋白的表达 ,应用原位末端标记法进行细胞凋亡检测。结果 本组 32例中凋亡细胞呈低密度 9例、高密度 2 3例 ;bcl 2蛋白表达阴性2 2例、阳性 10例 ;p5 3蛋白表达阴性 18例、阳性 14例。细胞凋亡与bcl 2蛋白表达呈负相关 ,与p5 3蛋白表达无关。结论 凋亡细胞密度和bcl 2蛋白表达对判断胃肠道MALT淋巴瘤的恶性程度和预后均有帮助
Objective To investigate the relationship between the apoptosis and the expression of bcl-2 and p53 protein in gastrointestinal mucosa-associated lymphoid tissue (MALT) lymphoma and the malignant degree and prognosis of MALT lymphoma. Methods 32 cases of gastrointestinal MALT lymphoma from January 1990 to December 1998 in our hospital were collected. The expressions of bcl 2 and p 5 3 protein were detected by immunohistochemical staining. The apoptosis was detected by in situ end labeling. Results The apoptotic cells in these 32 cases showed low density in 9 cases and high density in 23 cases. There were 22 cases with negative expression of bcl 2 protein and 10 cases with positive expression of p53 protein. The negative expression of p53 protein was found in 14 cases. Apoptosis was negatively correlated with bcl 2 protein expression, but not with p5 3 protein expression. Conclusion Apoptotic cell density and bcl 2 protein expression are helpful to judge the malignant degree and prognosis of MALT lymphoma in gastrointestinal tract