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检测１００例老年高血压患者（ＥＨＰ）和３０例正常人血浆肾素活性（ＰＲＡ）、心钠素（ＡＮＦ）浓度及左心室重量。结果表明：低肾素性ＥＨＰ血浆ＡＮＦ浓度增高，且与平均动脉压成正相关（ｒ＝０．４６８７，Ｐ＜０．０１），与ＰＲＡ成负相关（ｒ＝－０．４５３６，Ｐ＜０．０１）。伴左心室肥厚的ＥＮＰ血浆ＡＮＦ浓度明显高于Ⅰ期患者（Ｐ＜０．０ｌ），且左心室重量与血浆ＡＮＦ水平成正相关（ｒ＝０．７８９９，Ｐ＜０．０１）。血浆ＡＮＦ水平可作为高血压引起心肌结构，功能早期变化的指标之一。
The plasma renin activity (PRA), atrial natriuretic peptide (ANF) concentration and left ventricular mass were measured in 100 elderly hypertensive patients (EHP) and 30 healthy controls. The results showed that the concentration of ANF in low renin EHP plasma was increased and positively correlated with mean arterial pressure (r = 0.4687, P <0.01), and negatively correlated with PRA (r = -0.4536, P <0. 01). The level of ANF in ENP plasma with left ventricular hypertrophy was significantly higher than that in stage I patients (P <0.01), and the left ventricular weight was positively correlated with plasma ANF level (r = 0.7899, P <0.01). Plasma ANF levels can be used as one of the indicators of early changes in myocardial structure and function caused by hypertension.