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目的了解孕妇乙肝表面抗体(抗HBs)对儿童乙肝疫苗接种效果的长期影响。方法研究对象为106例抗HBs阳性和109例抗HBs阴性孕妇及其婴儿,检测孕妇产时外周血和新生儿脐带血抗HBs浓度,婴儿出生后接种5ug乙肝疫苗(0、1、6月),在儿童1岁半时检测血液抗HBs浓度。结果抗HBs阳性孕妇的新生儿脐带血中均含有抗HBs,84.9%的新生儿脐带血抗HBs浓度高于母亲外周血,抗HBs阳性孕妇组和抗HBs阴性孕妇组的儿童在1岁半时外周血抗HBs阳性率分别为89.6%和87.1%(P﹥0.05),抗HBs浓度几何均数分别为79.5IU/L和78.7IU/L(P﹥0.05),差异均无显著性。结论母亲乙肝表面抗体不影响儿童乙肝疫苗接种的长期效果。
Objective To understand the long-term effect of hepatitis B surface antibody (anti-HBs) in pregnant women on hepatitis B vaccination in children. Methods The subjects were 106 anti-HBs-positive and 109 anti-HBs-negative pregnant women and their infants. The anti-HBs concentrations in peripheral blood of pregnant women and umbilical cord blood of neonates were measured. After birth, 5ug hepatitis B vaccine was inoculated (0, 1, 6 months) Blood was tested for anti-HBs concentrations at 1 year and a half of childhood. Results The anti-HBs positive neonatal cord blood contained anti-HBs, 84.9% of the neonates had higher cord blood anti-HBs concentration than the mother’s peripheral blood, anti-HBs positive pregnant women and anti-HBs negative pregnant women in the age group of 1 year and a half The positive rates of anti-HBs in peripheral blood were 89.6% and 87.1%, respectively (P> 0.05). The geometric mean of anti-HBs concentrations were 79.5 IU / L and 78.7 IU / L, respectively. Conclusion Mother’s hepatitis B surface antibody does not affect the long-term effect of hepatitis B vaccination in children.