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原发性高血压患者中糖尿病的发病率显著高于非高血压人群。原发性高血压患者体内的肾素-血管紧张素系统(RAS)活性与其血糖水平呈正相关,而阻断RAS的药物可降低原发性高血压患者糖尿病的发病率;高血压患者血浆中炎性因子增加,一些药物可通过抑制炎性反应而阻止高血压患者并发糖尿病。RAS、炎性反应的活化均可通过降低体细胞对胰岛素的敏感性,从而引起或加重胰岛素抵抗或通过破坏胰岛B细胞最终形成糖尿病。
The incidence of diabetes mellitus in patients with essential hypertension is significantly higher than in non-hypertensive patients. The renin-angiotensin system (RAS) activity in patients with essential hypertension is positively correlated with its blood glucose level, while the drugs that block RAS can reduce the incidence of diabetes in patients with essential hypertension. In patients with hypertension, Increasing sexual factors, some drugs can prevent hypertension and hypertension in patients with diabetes. RAS, the activation of inflammatory responses can cause or aggravate insulin resistance by reducing the sensitivity of somatic cells to insulin or eventually form diabetes by destroying islet B cells.