多发性骨髓瘤(Multiple Myeloma,简称MM)是以骨髓浆细胞恶性增生为病理特点的一组疾病。临床表现常有骨骼疼痛、骨质破坏、贫血、肾功能不全、蛋白尿、本周氏蛋白尿、血钙过高、肝大及血清免疫球蛋白异常(1)。临床上常分为分泌型和非分泌型两大类。分泌型MM病人血清中除有异常增高的单克隆(或偶有双克隆)免疫球蛋白(M—Component,简称“M—成份”)以外,常伴有其它正常免疫球蛋白水平的低下,非 Multiple myeloma (Multiple Myeloma, referred to as MM) is a group of diseases characterized by pathological features of bone marrow plasma cell hyperplasia. Clinical manifestations often have skeletal pain, bone destruction, anemia, renal insufficiency, proteinuria, this week’s proteinuria, hypercalcemia, liver and serum immunoglobulin abnormalities (1). Clinically divided into secretory and non-secretory two categories. In addition to the abnormally elevated monoclonal (or occasional bi-clonal) immunoglobulin (M-Component) in the sera of patients with secreted MM, they are often accompanied by low or normal levels of other normal immunoglobulins