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呼吸机所致肺损伤(ventilator-induced lung,VILI)的发生机制目前尚不清楚。最近提出的生物伤(biotrauma)概念,认为机械通气引起的牵张可使炎性反应上调,引起肺组织甚至是全身器官的损伤。肺保护性通气和免疫调节治疗可在一定程度上减轻VILI。
The mechanism of ventilator-induced lung (VILI) is not yet clear. The recently proposed concept of biotrauma suggests that stretch induced by mechanical ventilation can upregulate the inflammatory response and cause damage to lung tissue and even to whole body organs. Pulmonary protective ventilation and immunomodulatory therapy may reduce VILI to some extent.