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目的 探讨小儿肾小球疾病的病理特点及其与临床表现的关系。方法 对 110例符合肾小球疾病诊断标准的小儿行肾活检术 ,肾组织送光镜、电镜及免疫荧光检查。结果 110例肾组织病理改变为 :IgA肾病 32例 (2 9.1% ) ;系膜增生 2 1例 (19.1% ) ;薄基底膜肾病 18例 (16 .4 % ) ;膜增生性肾炎、Alport综合征及微小病变各 6例 (5 .5 % ) ;局灶增生和轻微病变各 4例 (3.6 % ) ;新月体肾炎及增生硬化性肾炎各 3例 (2 .7% ) ;局灶节段性硬化、膜性肾病和IgM肾病各 2例 (1.8% ) ;毛细血管内皮增生 1例 (0 .9% )。 结论 相同的临床诊断 ,其病理表现可不同 ;相同的病理诊断 ,也可有不同的临床表现
Objective To investigate the pathological features of pediatric glomerular disease and its relationship with clinical manifestations. Methods One hundred and ten pediatric patients who met the diagnostic criteria of glomerular disease underwent kidney biopsy, transmission microscopy, electron microscopy and immunofluorescence. Results The pathological changes in 110 cases of renal tissue were as follows: IgA nephropathy in 32 cases (21.9%), mesangial hyperplasia in 21 cases (19.1%), thin basement membrane nephropathy in 18 cases (16.4%), membranoproliferative nephritis, Alport syndrome Lesions and minor lesions were found in 6 cases (5.5%), focal and hyperplastic lesions in 4 (3.6%), crescentic and proliferative glomerulonephritis in 3 (2.7%), and focal 2 cases (1.8%) had segmental sclerosis, membranous nephropathy and IgM nephropathy, and 1 case had capillary endothelial hyperplasia (0.9%). Conclusion The same clinical diagnosis, the pathological manifestations may be different; the same pathological diagnosis, but also have different clinical manifestations