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目的 探讨有机磷农药中毒中间综合征 (IMS)的诊断与治疗。方法 对 2 84例急性有机磷农药中毒出现的 14例IMS患者进行临床观察 ,对其进行综合分析。结果 IMS的发生率为 4 .93% ,急性中毒后 2～ 92h出现 ,平均 4 1.2h ;首发症状为声嘶、张口困难 ,多出现呼吸肌减弱和麻痹 ,症状持续 6～ 2 1d ,平均 11d ;死亡 2例。以对症治疗为主 ,多需及时建立人工气道和机械通气。结论 急性有机磷农药中毒病程中出现中间综合征应引起临床医生高度重视 ,出现声嘶、张口困难及对阿托品和胆碱酯酶复能剂疗效不佳时 ,应考虑本征。呼吸障碍时应及时采取人工机械通气
Objective To investigate the diagnosis and treatment of organophosphorus pesticide poisoning intermediate syndrome (IMS). Methods Fourteen patients with IMS who were infected by acute organophosphorus pesticide poisoning were enrolled in this study. The clinical data were analyzed comprehensively. Results The incidence of IMS was 4.93% .Acute poisoning occurred 2 ~ 92h after operation, with an average of 4 1.2 hours. The first symptom was hoarseness, difficulty in opening the mouth, more weakness and paralysis of the respiratory muscles, the symptoms persisted for 6 ~ 21 days, with an average of 11 days ; 2 died. To symptomatic treatment-based, multi-need to establish artificial airway and mechanical ventilation. Conclusion Acute organophosphorus pesticide poisoning in the course of intermediate syndrome should be caused by clinicians attention, hoarseness, mouth opening difficulties and the efficacy of atropine and cholinesterase agents poor, should consider the intrinsic. Breathing should be promptly taken artificial ventilation