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目的观察坎地沙坦联合卡维地洛治疗慢性充血性心力衰竭临床效果。方法选择我院2009年9月至2011年9月慢性充血性心力衰竭患者80例,上述患者随机分为观察组和对照组。两组均给予常规治疗,观察组给予卡维地洛及坎地沙坦治疗,对照组给予卡维地洛治疗。对两组患者治疗前和治疗后分别采用彩色多普勒测定两组患者是左室射血分数(LVEF)、左室收缩末期内径(LVESD)及左室舒张末期内径(LVEDD)。结果观察组治疗后左室射血分数、左室收缩末期内径及左室舒张末期内径与对照组治疗后比较,差异有统计学意义(P<0.05);观察组组总有效率显著高于对照组,差异有统计学意义(P<0.05)。结论坎地沙坦联合卡维地洛能够显著提高慢性充血性心力衰竭心功能,改善左室重构,临床效果显著。
Objective To observe the clinical effect of candesartan and carvedilol in the treatment of chronic congestive heart failure. Methods Eighty patients with chronic congestive heart failure from September 2009 to September 2011 in our hospital were randomly divided into observation group and control group. Both groups were given routine treatment, the observation group was given carvedilol and candesartan treatment, and the control group was given carvedilol treatment. Two groups of patients before and after treatment were measured by color Doppler, left ventricular ejection fraction (LVEF), left ventricular end-systolic diameter (LVESD) and left ventricular end-diastolic diameter (LVEDD). Results After treatment, left ventricular ejection fraction, end-diastolic diameter and left ventricular end-diastolic diameter in the observation group were significantly different from those in the control group (P <0.05). The total effective rate in the observation group was significantly higher than that in the control group Group, the difference was statistically significant (P <0.05). Conclusion Candesartan combined with carvedilol can significantly improve heart function in patients with chronic congestive heart failure and improve left ventricular remodeling. The clinical effect is significant.