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目的探讨氯气中毒后合并慢性阻塞性肺疾病急性发作患者相关炎性指标变化情况。方法 A组所选研究对象为2015年7月至2016年7月大连市第四人民医院收治的氯气中毒后合并慢性阻塞性肺疾病急性发作期患者42例;B组为该院同期收治的非氯气中毒的慢性阻塞性肺疾病急性发作患者,共42例;C组为同期于本院体检的42例健康体检者。分析3组研究对象的降钙素原、C反应蛋白、红细胞沉降率、纤维蛋白原及炎性反应因子白细胞介素6(IL-6)、白细胞介素8(IL-8)变化情况。结果 A组、B组降钙素原、C反应蛋白、红细胞沉降率、纤维蛋白原水平均明显高于C组,且A组降钙素原水平明显高于B组,差异均有统计学意义(均P<0.05);A组、B组IL-6、IL-8水平均明显高于C组,且A组IL-6、IL-8水平均明显高于B组,差异均有统计学意义(均P<0.05)。结论临床上加强降钙素原、C反应蛋白、红细胞沉降率、纤维蛋白原、IL-6、IL-8等相关炎性指标检测,能提升氯气中毒后合并慢性阻塞性肺疾病急性发作期患者诊断准确性。
Objective To investigate the changes of inflammatory markers in patients with acute exacerbation of chronic obstructive pulmonary disease after chlorine poisoning. Methods A group of patients selected for the study from July 2015 to July 2016 Dalian Fourth People’s Hospital admitted to chlorine poisoning after the merger of patients with acute exacerbation of chronic obstructive pulmonary disease in 42 cases; In the group of 42 patients with acute exacerbation of chronic obstructive pulmonary disease with chlorine poisoning, 42 patients were in the group C for the same period. The changes of procalcitonin, C-reactive protein, erythrocyte sedimentation rate, fibrinogen and inflammatory response factors IL-6 and IL-8 in the three groups were analyzed. Results The levels of procalcitonin, C-reactive protein, erythrocyte sedimentation rate and fibrinogen in group A and group B were significantly higher than those in group C, and the levels of procalcitonin in group A were significantly higher than those in group B P <0.05). The levels of IL-6 and IL-8 in group A and group B were significantly higher than those in group C, and the levels of IL-6 and IL-8 in group A were significantly higher than those in group B (All P <0.05). Conclusions Clinically, the detection of procalcitonin, C-reactive protein, erythrocyte sedimentation rate, fibrinogen, IL-6, IL-8 and other related inflammatory markers can improve the patients with acute exacerbation of chronic obstructive pulmonary disease after chlorine poisoning Diagnostic accuracy.