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目的:通过对正常宫颈上皮组织和宫颈鳞状细胞癌(CSCC)中Klotho和c-myc的检测,探讨两者在宫颈癌发生、发展过程中的作用及其相关性。方法:使用免疫组化SP法检测Klotho及c-myc在正常宫颈上皮组织及CSCC组织中的表达。结果:Klotho在正常宫颈组织中的表达显著高于CSCC组织,其表达与宫颈癌患者年龄、宫颈癌FIGO分期与淋巴结转移无关,差异无统计学意义(P>0.05)。c-myc在CSCC组织中的阳性表达明显高于正常宫颈上皮组织,其表达与组织学分级、FIGO分期及淋巴结转移有关,差异有统计学意义(P<0.05)。Klotho与c-myc的表达呈负相关(rs=-0.486,P<0.05)。结论:Klotho可能在宫颈癌的发病过程中起重要作用;c-myc与宫颈癌的侵袭及转移有关。联合检测Klotho与c-myc对宫颈癌的预防、早期诊断和治疗提供理论依据。
OBJECTIVE: To investigate the roles of Klotho and c-myc in the development and progression of cervical carcinoma by detecting Klotho and c-myc in normal cervical epithelium and cervical squamous cell carcinoma (CSCC). Methods: Immunohistochemical SP method was used to detect the expression of Klotho and c-myc in normal cervical epithelium and CSCC tissues. Results: The expression of Klotho in normal cervical tissue was significantly higher than that in CSCC. The expression of Klotho was not correlated with the age of cervical cancer, FIGO stage and cervical lymph node metastasis. There was no significant difference (P> 0.05). The positive expression of c-myc in CSCC was significantly higher than that in normal cervical epithelium. The expression of c-myc was correlated with the histological grade, FIGO stage and lymph node metastasis. The difference was statistically significant (P <0.05). Klotho and c-myc expression was negatively correlated (rs = -0.486, P <0.05). Conclusion: Klotho may play an important role in the pathogenesis of cervical cancer. C-myc is associated with the invasion and metastasis of cervical cancer. Combined detection of Klotho and c-myc on cervical cancer prevention, early diagnosis and treatment provide a theoretical basis.