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用溶菌板分析法测定了老年人长期下呼吸道感染者肺泡灌洗液(BALF)中溶菌酶(Lym)的水平,发现长期下呼吸道感染的老年人 BALF 中的 Lym 明显低于非下呼吸道感染的老年人(P<0.05),同时显示老年非下呼吸道感染者明显低于中青年对照组(P<0.05),中青年下呼吸道感染者明显高于非下呼吸道感染的同龄人(P<0.01)。说明老年人细胞免疫功能明显降低,长期肺部感染时更加重了细胞免疫功能的损害。这可能是老年人易感染,不易治愈和反复发作的原因之一。测定长期下呼吸道感染的老年患者 BALF 中的 Lym 有助于判断患者的免疫状况,对疾病的治疗及预后有一定的指导意义。
The level of lysozyme (Lym) in alveolar lavage fluid (BALF) in elderly patients with chronic lower respiratory tract infection was determined by lysozyme assay. Lym was found to be significantly lower in elderly patients with long-term lower respiratory tract infection than in non-lower respiratory tract infection (P <0.05). The elderly with non-lower respiratory tract infection were significantly lower than those of the young and middle-aged control group (P <0.05), and those with lower respiratory tract infection in middle-aged and younger patients were significantly higher than those without lower respiratory tract infection (P <0.01) . It shows that the cellular immune function of the elderly is obviously reduced, and the damage of cellular immune function is more aggravated when the pulmonary infection is long-term. This may be one of the reasons why the elderly are susceptible to infection, not curable and recurrent. The determination of Lym in BALF in elderly patients with long-term lower respiratory tract infection can help determine the patient’s immune status and provide some guidance for the treatment and prognosis of the disease.