目的分析厦门市疑似预防接种异常反应(adverse events following immunization,AEFI)发生特征,评价疫苗安全性和AEFI监测工作质量。方法根据《全国疑似预防接种异常反应监测方案》对监测系统相关指标进行分析。结果 2008—2012年厦门市共报告AEFI病例265例,报告发生率为30.7/100万;全年均有病例报告,无明显季节性;以1岁以下儿童为主(67.7%);主要为接种无细胞百白破及含麻类疫苗引起(55.9%);一般反应占61.1%,异常反应31.7%,偶合症占6.8%,心因性反应占0.4%;症状较轻,主要以发热、红肿、皮疹为主,占85.7%。结论厦门市AEFI监测工作逐步规范,但部分地区监测敏感性有待加强;疫苗接种工作安全可靠;可通过提高专业技术人员业务素质,减少AEFI的发生。 Objective To analyze the characteristics of suspected AEFI in Xiamen and evaluate the safety of the vaccine and the quality of AEFI monitoring. Methods According to “National Suspected Vaccination Abnormal Response Monitoring Program” to analyze the relevant indicators of the monitoring system. Results A total of 265 AEFI cases were reported in Xiamen from 2008 to 2012, with a reported incidence of 30.7 / 100 million. Cases were reported throughout the year with no seasonal manifestations. Children under 1 year old (67.7%) were mainly vaccinated Amebiasis and hemp-containing vaccine (55.9%); general reaction accounted for 61.1%, abnormal reaction 31.7%, coupling accounted for 6.8%, psychogenic reactions accounted for 0.4%; mild symptoms, mainly in fever, redness , Rash-based, accounting for 85.7%. Conclusion The monitoring of AEFI in Xiamen City has been gradually standardized. However, the sensitivity of surveillance in some areas needs to be strengthened. Vaccination work is safe and reliable. AEFI can be reduced by improving the professional quality of professional technicians.