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心痛定是硝苯吡啶的商品名称,即Nifedipine。系一种二氢吡啶的衍生物,属新型钙拮抗剂或“慢通道阻滞剂”。于1970年在日本生产并用于临床后,因认为其具有作用快而强,疗效好,不良反应小的特点,故迅速广泛用于治疗某些心血管疾病。近年甚至有人提出,心痛定可取代利尿剂作为老年人高血压治疗的一线药物。以往仅发现其有面红发热、头昏头痛、或(和)心悸、低血压等不良反应。但近年由于心痛定使用日益广泛,临床资料积累甚丰,所以对其不良反应又有新的发现。其中有些不良反应还是十分严重的,对病人康复极为不利,尤其是对机体功能日趋衰弱的老年人尤宜注意。现将笔者临床所见并结合近年有关文献,将硝苯吡啶新的不良反应综述如下:
Nifedipine is nifedipine’s trade name, namely Nifedipine. A dihydropyridine derivative, a new type of calcium antagonist or “slow channel blocker.” Was produced in Japan in 1970 and used in clinical practice. It is rapidly and widely used for the treatment of certain cardiovascular diseases because of its quick and strong effect, good curative effect and small adverse reaction. In recent years, it was even suggested that heartache may replace diuretics as a first-line drug for the treatment of hypertension in the elderly. In the past only found that it has red fever, dizziness, headache, and (and) heart palpitations, hypotension and other adverse reactions. However, due to the increasing use of nifedipine in recent years, clinical data have accumulated very abundant, so its adverse reactions have new discoveries. Some of these adverse reactions are still very serious, extremely bad for the patient’s recovery, especially for the elderly who are increasingly weakened body function should pay special attention. Now I see the clinical and combined with recent literature, the new side effects of nifedipine summarized as follows: