晚近动物实验表明,钙拮抗剂(包括异搏停)能保护动物免患动脉粥样硬化(AS),也可使AS消退。作者将从人主动脉粥样硬化病灶、黄斑或动脉粥样斑块分离的细胞进行初培养,保留其“AS”细胞的基本性质,即增殖活性增高,细胞内脂肪含量高以及细胞外基质结缔组织成分(主要是胶原)增加,以确定异搏停能否使培养的“AS”指数正常化,即能否对动脉细胞有效。研究的项目包括:观察人内皮下内膜细胞的切培养;确定培养细胞的 Recent animal experiments show that calcium antagonists (including verapamil) can protect animals from atherosclerosis (AS), but also make AS subsided. The authors initially culture cells isolated from human aortic atherosclerotic lesions, macula or atherosclerotic plaque, retaining the essential properties of their “AS” cells, namely increased proliferative activity, high intracellular fat content, and extracellular matrix connective Tissue composition (mainly collagen) increased to determine whether verapamil could normalize the cultured “AS” index, ie, whether it is effective on arterial cells. The research projects include: observation of human subcutaneous endometrial cell culture; to determine the cultured cells