用精制鱼油、磷脂、脂肪酸甘油酯分别与5-氟尿嘧啶制成3种口服制剂:5-FU-PUFA、5-FU-P、5-FU-G,以小鼠肉瘤180（Sarcoma 180,S180）、艾氏实体瘤（Ehrlich carcinoma,ESC）为模型,进行抗癌活性研究,实验结果表明的抑瘤率较市售5-FU片剂提高10％,毒性显著降低（5-FU-PUFA和5-FU片剂的LD50分别为231.26mg·kg-1和104.29mg·kg-1）;5-FU-P、5-FU-G的抑瘤率及毒性与5-FU片剂无显著差别。 Three oral preparations were made from refined fish oil, phospholipids, and fatty acid glycerides respectively with 5-fluorouracil: 5-FU-PUFA, 5-FU-P, 5-FU-G, and mouse sarcoma 180 (Sarcoma 180, S180) Ehrlich carcinoma (ESC) was used as a model to study anti-cancer activity. The experimental results showed that the tumor inhibition rate was 10% higher than that of commercial 5-FU tablets, and the toxicity was significantly reduced (5-FU-PUFA and 5). The LD50 of -FU tablets was 231.26 mg·kg-1 and 104.29 mg·kg-1, respectively; the inhibitory rate and toxicity of 5-FU-P and 5-FU-G were not significantly different from those of 5-FU tablets.