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人和动物的胚胎发育中,肝脏是一个重要的造血器官。在小鼠胚胎第10天,人类胎儿发育第2月起,就开始了肝脏造血。随着胚胎的发育,造血组织中造血干细胞的数量及性能也随之发生相应的变化。用体外细胞团培养的方法可检出胎肝内含有大量的红系造血祖细胞(CFU—E)及粒系造血祖细胞(CFU—C)。这是人和动物进行胎肝移植后具有全面重建造血功能的主要物质基础。
In human and animal embryo development, the liver is an important hematopoietic organ. On the 10th day of the mouse embryo, the human hematopoiesis began on the twelfth day of fetal development. As the embryo develops, the number and performance of hematopoietic stem cells in the hematopoietic tissue also change accordingly. In vitro cell mass culture method can be detected in the fetal liver contains a large number of erythroid hematopoietic progenitor cells (CFU-E) and granulocyte-derived hematopoietic progenitor cells (CFU-C). This is the main material basis for the comprehensive reconstruction of hematopoiesis after human and animal fetal liver transplantation.