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EDTA(乙二胺四乙酸)是一种常用的防止金属离子催化氧化以保持某些液体药剂稳定性的重要物质。但本品在药剂学中归属于何类物质,各书不一,或列入抗氧剂,或列入金属络合剂,或在同一书内,即作为金属螯合剂,又列入金属络合剂。该物究竟归属于何类物质为适?兹作如下讨论。 1.抗氧剂系还原剂,是一类极易氧化的物质,如常用的Na_2SO_3、Na_2S_2O_3、NaHSO_3、Na_2S_2O_5等,加入易氧化药物的溶液中之后,它们首先接触到溶媒中或容器空间内的氧发生氧化从而保护药物使之稳定。但EDTA并非还原剂,它的抗氧作用是通过与碱土金属、重金属生成稳定的螫合物从而消除了金属离子的催化氧化来实现的,这与抗氧剂的物质概念、化学性质及作用原理截然不同,故EDTA不应
EDTA (ethylenediaminetetraacetic acid) is a commonly used important material that prevents the catalytic oxidation of metal ions to maintain the stability of certain liquid pharmaceuticals. But this product belongs to the pharmacy in what kind of material, different books, or included in the antioxidant, or included in the metal complexing agent, or in the same book, that is, as a metal chelator, but also included in the metal network mixture. What kind of substance should be attributed to this matter? The following discussion. 1. Antioxidant system reductant is a class of easily oxidized substances, such as commonly used Na_2SO_3, Na_2S_2O_3, NaHSO_3, Na_2S_2O_5 and so on, after adding easily oxidized drug solution, they first come into contact with the solvent or in the container space Oxygen is oxidized to protect the drug and stabilize it. However, EDTA is not a reducing agent. Its antioxidant function is achieved through the formation of stable compounds with alkaline earth metals and heavy metals, thereby eliminating the catalytic oxidation of metal ions. This is consistent with the concept, chemistry and principle of action of antioxidants Different, so EDTA should not