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目的探讨ICU重症颅脑损伤患者应用添加谷氨酰胺的肠外营养的临床效果。方法选取ICU重症颅脑损伤患者120例为研究对象。按照随机数字表法将120例患者分为实验组和对照组,每组患者60例。实验组患者予以添加谷氨酰胺的肠外营养支持,对照组则予以常规肠外营养支持。观察2组患者体内的血清总蛋白(TP)、白蛋白(ALB)水平,并发症发生情况及营养不良炎症评分(malnutrition-inflammation score,MIS)评分。结果实验组患者经治疗后血清TP、ALB水平均显著高于对照组(P<0.001)。实验组患者并发症发生率为15.0%,明显低于对照组并发症发生率55.0%(χ~2=21.099,P<0.001)。实验组患者经治疗后MIS评分正常患者明显高于对照组(70.0%vs.33.3%,χ~2=16.151,P<0.001)。结论添加谷氨酰胺的肠外营养支持治疗法治疗重型颅脑损伤患者可以有效改善其机体术后营养状况,加强营养支持,治疗效果好,对患者病情恢复效果显著。
Objective To investigate the clinical effect of adding glutamine to parenteral nutrition in patients with severe craniocerebral injury in ICU. Methods 120 ICU patients with severe craniocerebral injury were selected as the research object. According to the random number table method, 120 patients were divided into experimental group and control group, 60 cases in each group. Patients in the experimental group were given parenteral nutrition supplementation of glutamine, while those in the control group were given routine parenteral nutrition support. The levels of serum total protein (TP), albumin (ALB), complications and malnutrition-inflammation score (MIS) score in two groups were observed. Results The levels of TP and ALB in the experimental group were significantly higher than those in the control group after treatment (P <0.001). The incidence of complication in experimental group was 15.0%, which was significantly lower than that in control group (55.0%, χ ~ 2 = 21.099, P <0.001). The experimental group of patients with normal MIS score after treatment was significantly higher than the control group (70.0% vs.33.3%, χ ~ 2 = 16.151, P <0.001). Conclusion Addition of glutamine in patients with severe craniocerebral injury treated with parenteral nutrition support therapy can effectively improve the postoperative nutritional status of the patients and enhance nutritional support. The treatment effect is good and the patient’s condition recovery effect is remarkable.