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目的分析儿童广州管圆线虫病的临床特点及死亡原因提高对儿童广州管圆线虫病的认识。方法对3例死亡病例的临床资料及尸体解剖、病理切片结果进行回顾性分析,并复习国内外相关文献。结果3例死亡病例均有广州管圆线虫虫体栓塞肺动脉,形成肉芽肿性肺炎,临床表现为肺炎和呼吸衰竭;脑脊液嗜酸性粒细胞计数不高,未发现幼虫,脑组织肉芽肿性脑膜炎;异位寄生1例,寄生于左眼前房。3例均死于呼吸衰竭。结论儿童广州管圆线虫病主要侵犯肺和脑组织,易误诊为肺炎和脑膜炎,呼吸衰竭是导致死亡的主要原因。
Objective To analyze the clinical features and the cause of death of angiostrongyliasis in children in Guangzhou and to raise awareness of angiostrongyliasis in children in Guangzhou. Methods The clinical data of 3 death cases and the results of autopsy and pathological examination were retrospectively analyzed and the related literatures at home and abroad were reviewed. Results All the 3 deaths were caused by embolization of pulmonary artery with C. elegans to form granulomatous pneumonia. The clinical manifestations were pneumonia and respiratory failure. Cerebrospinal fluid eosinophil count was not high, and larva and brain granulomatous meningitis were not found One case of ectopic parasitism parasitized the left anterior chamber. 3 patients died of respiratory failure. Conclusions Children angiostrongychiasis mainly affects lung and brain tissues and is easily misdiagnosed as pneumonia and meningitis. Respiratory failure is the leading cause of death.