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目的 研究帕金森病（Ｐｒｋｉｎｓｏｎ ｄｉｓｅａｓｅ，ＰＤ）嗓音特征。方法 ７９例ＰＤ病例组、４０例正常人对照组发持续元音／ａ：／３次，每次发声维持三秒以上，声强控制在７０±４ｄＢ，记录嗓音，计算基频（Ｆ０）、频率微扰（ｊｉｔｔｅｒ）、振幅微扰（ｓｈｉｍｍｅｒ）、谐噪比（ＨＮＲ）。结果ＰＤ组频率微扰高于对照组，有统计学意义（Ｐ＜０．０１）。结论ＰＤ嗓音主要特点是：高频率微扰、高振幅微扰、低Ｆ０、低ＨＮＲ。
Objective To study the voice features of Parkinson’s disease (PD). Methods 79 patients with PD and 40 healthy controls were enrolled in continuous vowel / a: 3 times. Each vocalization was maintained for more than three seconds. The sound intensity was controlled at 70 ± 4dB. The voice was recorded and the fundamental frequency (F0) Frequency jitter, amplitude shimmer, harmonic-to-noise ratio (HNR). Results The frequency of PD group perturbation was higher than that of the control group, with statistical significance (P <0.01). Conclusion PD voice main features are: high frequency perturbation, high amplitude perturbation, low F0, low HNR.