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目的:探讨脂多糖、血清降钙素原检测在乙肝肝硬化合并自发性细菌性腹膜炎患者中的临床价值。方法:选取2011年1月—2013年12月在我院接受治疗的65例乙肝肝硬化患者,其中有33例合并自发性细菌性腹膜炎的患者作为观察组,其余32例未合并自发性细菌性腹膜炎的患者作为对照组,分别检测两组的脂多糖和人血清降钙素原。结果:观察组的脂多糖水平为(104±88)pg/mL,血清降钙素水平为(15±5)ng/mL。对照组脂多糖水平为(34±16)pg/mL,血清降钙素水平为(7±2)ng/mL。观察组的血浆脂多糖、血清降钙素水平显著高于对照组。乙肝肝硬化合并自发性细菌性腹膜炎患者接受治疗48小时后,脂多糖水平所有升高,治疗前后无显著性差异(P>0.05)。血清降钙素有所降低,治疗前后有显著性差异(P<0.05)。结论:脂多糖、血清降钙素原检测,有利于提高乙肝肝硬化合并自发性细菌性腹膜炎患者诊断准确性,为临床诊治提供可靠依据。
Objective: To investigate the clinical value of detecting lipopolysaccharide and serum procalcitonin in patients with hepatitis B cirrhosis complicated with spontaneous bacterial peritonitis. Methods: From January 2011 to December 2013 in our hospital for treatment of 65 patients with hepatitis B cirrhosis, 33 patients with spontaneous bacterial peritonitis in patients as the observation group, the remaining 32 patients without spontaneous bacterial Peritonitis patients as a control group were detected in two groups of lipopolysaccharide and human serum procalcitonin. Results: The level of lipopolysaccharide in the observation group was (104 ± 88) pg / mL and the level of serum calcitonin was (15 ± 5) ng / mL. The level of lipopolysaccharide in the control group was (34 ± 16) pg / mL and the level of serum calcitonin was (7 ± 2) ng / mL. The observation group, plasma lipopolysaccharide, serum calcitonin levels were significantly higher than the control group. Hepatic cirrhosis with spontaneous bacterial peritonitis in patients receiving 48 hours after treatment, all levels of lipopolysaccharide increased before and after treatment was no significant difference (P> 0.05). Serum calcitonin decreased, before and after treatment were significantly different (P <0.05). Conclusion: The detection of lipopolysaccharide and serum procalcitonin is beneficial to improve the diagnostic accuracy of hepatitis B cirrhosis patients with spontaneous bacterial peritonitis and provide a reliable basis for clinical diagnosis and treatment.