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目的:探讨妥泰对小儿各型癫痫发作的疗效、剂量及安全性。方法:对120例不同发作类型的小儿癫痫患儿给予妥泰添加和单药治疗,起始剂量为0.25～1.0 mg(kg·d),每周增加0.5～1.0 mg(kg·d)至发作完全控制或达推荐剂量4～8 mg(kg·d)(最大200 mg/d)。结果:总有效率达82.50%,副作用多表现为一过性的嗜睡、食欲减低、不安、疲劳、体重下降、行为异常等。结论:妥泰是一种新型有效广谱的抗癫痫药,对各总类型小儿癫痫发作均有效,起始量小、缓慢加量是防止不良反应的有效方法之一,也因根据发作类型和发作频率调整加量速度。
Objective: To investigate the efficacy, dose and safety of topiramate in children with various types of seizures. Methods: One hundred and twenty children with epilepsy of epilepsy with different seizure types were treated with topiramate and monotherapy. The initial dose was 0.25-1.0 mg (kg · d), 0.5-1.0 mg (kg · d) weekly to onset Completely controlled or recommended dose of 4 ~ 8 mg (kg · d) (up to 200 mg / d). Results: The total effective rate was 82.50%. The side effects were transient sleepiness, loss of appetite, anxiety, fatigue, weight loss and abnormal behavior. Conclusion: Topotecan is a new type of broad-spectrum anti-epileptic drugs. It is effective in all types of pediatric seizures. Small amounts and slow dosage are effective methods to prevent adverse reactions. Also, according to the types of attacks and Attack frequency adjustment plus speed.